Biostatistics Curriculum at Aiph University Bhubaneswar
The Biostatistics program at Aiph University Bhubaneswar is structured to provide a rigorous yet flexible academic experience that prepares students for careers in research, industry, and public health. The curriculum spans eight semesters and integrates foundational sciences with advanced statistical concepts and practical applications.
| Semester | Course Code | Course Title | Credit Structure (L-T-P-C) | Prerequisites |
|---|---|---|---|---|
| 1 | MATH101 | Calculus I | 3-0-0-3 | - |
| 1 | MATH102 | Linear Algebra | 3-0-0-3 | - |
| 1 | BIO101 | Introduction to Biology | 3-0-0-3 | - |
| 1 | CHEM101 | Chemistry for Biological Sciences | 3-0-0-3 | - |
| 1 | COMP101 | Programming Fundamentals | 2-0-2-2 | - |
| 1 | STAT101 | Introduction to Statistics | 3-0-0-3 | - |
| 2 | MATH201 | Calculus II | 3-0-0-3 | MATH101 |
| 2 | STAT201 | Probability Theory | 3-0-0-3 | STAT101 |
| 2 | BIO201 | Molecular Biology | 3-0-0-3 | BIO101 |
| 2 | COMP201 | Data Structures and Algorithms | 2-0-2-2 | COMP101 |
| 2 | STAT202 | Statistical Inference | 3-0-0-3 | STAT201 |
| 2 | LIT101 | English for Academic Purposes | 2-0-0-2 | - |
| 3 | STAT301 | Regression Analysis | 3-0-0-3 | STAT202 |
| 3 | BIO301 | Genetics and Genomics | 3-0-0-3 | BIO201 |
| 3 | STAT302 | Experimental Design | 3-0-0-3 | STAT202 |
| 3 | COMP301 | Statistical Software Lab | 0-0-4-2 | COMP201 |
| 3 | MATH301 | Differential Equations | 3-0-0-3 | MATH201 |
| 3 | STAT303 | Survey Sampling Techniques | 3-0-0-3 | STAT202 |
| 4 | STAT401 | Survival Analysis | 3-0-0-3 | STAT301 |
| 4 | BIO401 | Epidemiology | 3-0-0-3 | BIO301 |
| 4 | STAT402 | Bayesian Statistics | 3-0-0-3 | STAT302 |
| 4 | COMP401 | Advanced Data Analysis | 2-0-2-2 | COMP301 |
| 4 | STAT403 | Multivariate Statistics | 3-0-0-3 | STAT301 |
| 5 | STAT501 | Clinical Trial Design | 3-0-0-3 | STAT402 |
| 5 | BIO501 | Public Health and Policy | 3-0-0-3 | BIO401 |
| 5 | STAT502 | Computational Biology | 3-0-0-3 | STAT403 |
| 5 | COMP501 | Machine Learning for Biostatistics | 2-0-2-2 | COMP401 |
| 5 | STAT503 | Advanced Statistical Modeling | 3-0-0-3 | STAT502 |
| 6 | STAT601 | Genomic Data Analysis | 3-0-0-3 | STAT503 |
| 6 | BIO601 | Global Health Challenges | 3-0-0-3 | BIO501 |
| 6 | STAT602 | Meta-Analysis and Systematic Reviews | 3-0-0-3 | STAT501 |
| 6 | COMP601 | Big Data Analytics in Health | 2-0-2-2 | COMP501 |
| 6 | STAT603 | Statistical Software Development | 3-0-0-3 | STAT602 |
| 7 | STAT701 | Capstone Project I | 0-0-8-4 | STAT603 |
| 7 | BIO701 | Health Informatics | 3-0-0-3 | BIO601 |
| 7 | STAT702 | Research Ethics and Integrity | 2-0-0-2 | - |
| 8 | STAT801 | Capstone Project II | 0-0-8-4 | STAT701 |
| 8 | BIO801 | Internship in Biostatistics | 0-0-6-3 | BIO701 |
Detailed Course Descriptions
Here are detailed descriptions of some advanced departmental elective courses:
1. Machine Learning for Biostatistics
This course introduces students to modern machine learning algorithms specifically tailored for biostatistical applications. Topics include supervised and unsupervised learning, neural networks, decision trees, support vector machines, clustering methods, and deep learning architectures. Students learn how to apply these techniques to real-world biological datasets, such as gene expression profiles and patient outcome predictions.
2. Clinical Trial Design
Students explore the principles of designing, conducting, and analyzing clinical trials. The course covers phase I-IV trial designs, randomization strategies, sample size calculations, interim analyses, safety monitoring, and regulatory requirements. Practical examples from recent drug development programs are used to illustrate key concepts.
3. Genomic Data Analysis
This course focuses on statistical methods for analyzing genomic data. Students learn about sequence alignment, variant calling, gene expression analysis, pathway enrichment, and epigenetic modifications. The curriculum includes hands-on labs using tools like SAMtools, GATK, and R/Bioconductor packages.
4. Big Data Analytics in Health
This course addresses the challenges of managing and analyzing large-scale health datasets. Students study distributed computing frameworks like Apache Spark, data warehousing concepts, cloud-based platforms (AWS, Google Cloud), and real-time data processing pipelines. Case studies from electronic health records and wearable devices are analyzed.
5. Statistical Software Development
This course teaches students how to develop custom statistical software tools for biostatistical applications. Students learn programming languages like R and Python, object-oriented design principles, package development, testing procedures, and documentation practices. Projects include building reusable functions for common biostatistical tasks.
6. Advanced Statistical Modeling
Students delve into complex modeling techniques such as generalized linear models, mixed-effects models, spatial statistics, time series analysis, and hierarchical Bayesian models. Applications in epidemiology, clinical research, and environmental science are emphasized throughout the course.
7. Meta-Analysis and Systematic Reviews
This course provides students with the skills needed to conduct systematic reviews and meta-analyses of published literature. Topics include study selection criteria, risk of bias assessment, effect size calculations, heterogeneity analysis, publication bias detection, and reporting guidelines (PRISMA). Students complete a full meta-analysis project.
8. Computational Biology
This course bridges the gap between computational methods and biological systems. Students learn about sequence databases, phylogenetic analysis, protein structure prediction, metabolic pathway modeling, and systems biology approaches. Tools like BLAST, Pfam, STRING, and Cytoscape are introduced.
9. Health Informatics
This course explores the intersection of health information technology and biostatistics. Students study electronic health records (EHRs), data interoperability standards (FHIR), clinical decision support systems, privacy and security issues, and data governance frameworks. Practical assignments involve working with real EHR datasets.
10. Research Ethics and Integrity
This course emphasizes the ethical considerations in conducting biostatistical research. Topics include informed consent, data privacy, conflict of interest, reproducibility, responsible conduct of research, and institutional review board (IRB) processes. Students engage in case studies and discussions to enhance their understanding of ethical dilemmas.
Project-Based Learning Approach
The department strongly advocates for project-based learning as a core component of the curriculum. Students begin working on mini-projects in their third year, focusing on specific biostatistical problems relevant to current research interests. These projects are typically interdisciplinary and involve collaboration with faculty members or external organizations.
Mini-projects are evaluated based on research design, data analysis skills, reproducibility, clarity of presentation, and impact potential. Students are required to submit progress reports at regular intervals and present their findings in a departmental seminar series.
The final-year thesis/capstone project is a significant undertaking that allows students to demonstrate mastery of biostatistical concepts and methodologies. Projects can be theoretical, computational, or applied in nature, depending on the student's interest and career goals. Faculty mentors guide students through every stage of the project, from topic selection to final presentation.
Students are encouraged to propose their own research ideas or select from a list of faculty-approved topics. The department maintains a repository of previous projects for inspiration and guidance. Regular meetings with advisors ensure that projects remain aligned with academic standards and practical relevance.